AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells[1].
Molecular Weight:
526.36
Purity:
98.12
CAS Number:
[2374740-21-1]
Formula:
C23H23Cl2F2N5O3
Target:
Akt,Apoptosis
Application Notes:
MCE Product type: Reference compound
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