NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCalpha[1]. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure[2].
Molecular Weight:
207.23
Purity:
99.98
CAS Number:
[64091-91-4]
Formula:
C10H13N3O2
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound
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