Y16 is a specific inhibitor of Leukemia-associated Rho guanine nucleotide exchange factor (LARG) with a Kd value of 76 nM. Y16 is active in blocking the interaction of LARG and related G-protein-coupled Rho GEFs with RhoA. Y16 shows no detectable effect on other diffuse B-cell lymphoma (Dbl) family Rho GEFs, Rho effectors, or a RhoGAP[1].
Molecular Weight:
384.43
Purity:
98.10
CAS Number:
[429653-73-6]
Formula:
C24H20N2O3
Target:
Ras
Application Notes:
Reference compound
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