GNF362 is a selective, potent, and orally bioavailable inhibitor of inositol trisphosphate 3 kinase B (Itpkb) with an IC50 of 9 nM. GNF362 also inhibits Itpka and Itpkc with IC50 values of 20 nM and 19 nM, respectively. Inositol trisphosphate 3 kinase B (Itpkb) is a Ca2+-dependent kinase, which phosphorylates the 3 position of Ins (1,4,5) P3 to generate inositol 1,3,4,5-tetrakisphosphate [Ins (1,3,4,5) P4][1].
Molecular Weight:
426.44
Purity:
99.86
CAS Number:
[1003019-41-7]
Formula:
C22H21F3N6
Target:
Phosphatase
Application Notes:
MCE Product type: Reference compound1
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