Hecogenin acetate is an orally active steroid saponin aglycone with extensive biological activities. Hecogenin acetate inhibits the phosphorylation of NF-kappaB and p38 MAPK signaling pathways, antagonizes TRPA1/TRPM8 channels, inhibits the production of pro-inflammatory cytokines, and has anti-inflammatory and analgesic effects. Hecogenin acetate inhibits the production of ROS and the activation of NLRP3 inflammasome, downregulates the expression of MMP-2, and has neuroprotective and anti-tumor activities. Hecogenin acetate enhances gastric mucosal defense and promotes ulcer healing. Hecogenin acetate can be used in combination with certain antibiotics to regulate bacterial efflux pumps and restore antibiotic sensitivity[1][2][3][4][5].
Molecular Weight:
472.66
Purity:
98.57
CAS Number:
[915-35-5]
Formula:
C29H44O5
Target:
ERK,Interleukin Related,MMP,NF-kappaB,NOD-like Receptor (NLR),p38 MAPK,Reactive Oxygen Species (ROS),TNF Receptor,TRP Channel
Application Notes:
MCE Product type: Natural Products
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