Polyquaternium-1 (Polidronium chloride, PQ-1) is an antimicrobial preservative and an activator of NF-kappaB. Polyquaternium-1 targets bacterial cell membranes, commonly used in ophthalmic surgery. Polyquaternium-1 adsorbs to the surface of microbial membranes through its polycationic properties, destroying membrane integrity and inducing potassium ion leakage, leading to bacterial death. Polyquaternium-1 exerts antimicrobial effects at a concentration of 0.001% and has low toxicity to mammalian cells. Polyquaternium-1 can be used to prepare products such as glaucoma eye drops (Travoprost preparations containing PQ-1), artificial tears, and contact lens solutions to reduce the ocular surface toxicity of traditional preservatives such as benzalkonium chloride (HY-B2232)[1][2][3].
Purity:
99
CAS Number:
[75345-27-6]
Formula:
(C6H12N)nC16H36N2O6.3Cl
Target:
Biochemical Assay Reagents
Application Notes:
MCE Product type: Reference compound
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