GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the beta4 and beta5 subunits (IC50=0.16 µM for WT L. donovani proteasomes). GSK3494245 moderately inhibits chymotrypsin-like activity of human proteasome (IC50: purified 26S=13 µM, enriched THP-1 extracts IC50=40µM). GSK3494245 exhibits attractive biological and biosafety properties[1][2].
Molecular Weight:
410.44
Purity:
98.66
CAS Number:
[2080410-41-7]
Formula:
C21H23FN6O2
Target:
Parasite,Proteasome
Application Notes:
MCE Product type: Reference compound
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