Q8, an effective antiangiogenic drug, is a CysLt1 antagonist (IC50 of 4.9 µM). Q8 is sufficient to reduce cellular levels of NF-kappaB and calpain-2 and secreted levels of the proangiogenic proteins intercellular adhesion molecule-1, vascular cell adhesion protein-1, and VEGF[1].
Molecular Weight:
299.75
CAS Number:
[1541762-55-3]
Formula:
C17H14ClNO2
Target:
Leukotriene Receptor
Application Notes:
MCE Product type: Reference compound
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