Mofarotene (Ro 40-8757), an arotinoid, is anticancer compound. Mofarotene induces apoptosis, associated with mitochondrial membrane depolarization, activation of caspase-3 and -9, and enhanced production of reactive oxygen species. Mofarotene inhibits hematopoiesis in vitro by inhibiting maturation from primitive progenitor cells[1][2][3].
Molecular Weight:
433.63
CAS Number:
[125533-88-2]
Formula:
C29H39NO2
Target:
Apoptosis,Caspase,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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