GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. GSK143 dihydrochloride inhibits phosphorylated Erk (pErk: pIC50=7.1)[1]. GSK143 dihydrochloride reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice[2][3].
Molecular Weight:
415.32
Purity:
99.37
CAS Number:
[2341796-81-2]
Formula:
C17H24Cl2N6O2
Target:
ERK,Syk
Application Notes:
MCE Product type: Reference compound
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