Sotuletinib (BLZ945) hydrochloride is a potent, selective, orally active and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs. Sotuletinib hydrochloride can be used for microglia depletion, and for tumor and CNS-related disease research.[1].
Molecular Weight:
434.94
Purity:
99.43
CAS Number:
[2222138-31-8]
Formula:
C20H23ClN4O3S
Target:
c-Fms
Application Notes:
MCE Product type: Reference compound
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