Cycloguanil (hydrochloride), CAS [[152-53-4]]

Product Overview

• Article Name: Cycloguanil (hydrochloride), CAS [[152-53-4]]
• Biozol Catalog Number: MCE-HY-12784A
• Supplier Catalog Number: HY-12784A
• Alternative Catalog Number: MCE-HY-12784A-100MG,MCE-HY-12784A-5MG,MCE-HY-12784A-25MG,MCE-HY-12784A-10MMX1ML,MCE-HY-12784A-50MG,MCE-HY-12784A-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: Chlorguanide triazine (hydrochloride)

Product Description

Cycloguanil (Chlorguanide triazine) hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 10.8 µM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity[1][2].

Product Properties

• Molecular Weight: 288.18
• Purity: 99.93
• CAS Number: [152-53-4]
• Formula: C11H15Cl2N5
• Target: Antifolate,DNA/RNA Synthesis,Parasite,STAT

Application Notes

• Application Notes: MCE Product type: Reference compound