Vps34-IN-1 is a potent and selective inhibitor of class III Vps34 PI3K. Vps34-IN-1 inhibits phosphorylation of PtdIns by recombinant insect cell expressed Vps34-Vps15 complex with an IC50 of ~25 nM. Vps34-IN-1 can suppress SGK3 activation by reducing PtdIns(3)P levels via lowering phosphorylation of T-loop and hydrophobic motifs. Vps34-IN-1 modulates autophagy[1][2][3].
Molecular Weight:
425.91
Purity:
99.79
CAS Number:
[1383716-33-3]
Formula:
C21H24ClN7O
Target:
Autophagy,PI3K
Application Notes:
MCE Product type: Reference compound
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