Netarsudil (AR-13324) hydrochloride is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil hydrochloride reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil hydrochloride is mainly used in the study of ocular hypertension and primary open-angle glaucoma[1][2][3][4].
Molecular Weight:
526.45
Purity:
99.90
CAS Number:
[1253952-02-1]
Formula:
C28H29Cl2N3O3
Target:
ROCK
Application Notes:
MCE Product type: Reference compound
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