MLS1547 is a highly efficacious G protein-biased dopamine D2 receptor (D2R) agonist (Ki=1.2 µM). MLS1547 stimulates D2R G protein-mediated signaling (EC50=0.37 µM in a calcium mobilization assay). MLS1547 acts as an antagonist for dopamine (DA)-stimulated beta-arrestin recruitment to the D2R (IC50=9.9 µM)[1][2].
Molecular Weight:
354.83
Purity:
99.94
CAS Number:
[315698-36-3]
Formula:
C19H19ClN4O
Target:
Dopamine Receptor
Application Notes:
MCE Product type: Reference compound
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