ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 µM, 3 µM for ERK5 and ERK5 MEF2D, respectively. ERK5-IN-2 does not interact with the BRD4 bromodomain. ERK5-IN-2 suppresses both tumor xenograft growth and basic fibroblast growth factor (bFGF) driven Matrigel plug angiogenesis[1].
Molecular Weight:
388.19
Purity:
98.96
CAS Number:
[1888305-96-1]
Formula:
C17H11BrFN3O2
Target:
ERK
Application Notes:
MCE Product type: Reference compound
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