PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis[1].
Molecular Weight:
424.52
Purity:
99.92
CAS Number:
[2173556-69-7]
Formula:
C22H24N4O3S
Target:
RIP kinase
Application Notes:
MCE Product type: Reference compound1
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