BT173 is a potent homeodomain interacting protein kinase 2 (HIPK2) inhibitor. BT173 binds to HIPK2 and does not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. BT173 attenuates renal fibrosis through suppression of the TGF-beta1/Smad3 pathway. BT173 can be studied in research for kidney diseases such as renal fibrosis[1].
Molecular Weight:
382.21
Purity:
98.71
CAS Number:
[2232180-74-2]
Formula:
C18H12BrN3O2
Target:
DYRK
Application Notes:
MCE Product type: Reference compound
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