6-Thioinosine (6TI) is a purine antimetabolite and an anti-adipogenic agent. 6-Thioinosine reduces the mRNA levels of PPARgamma and C/EBPalpha and downregulates the mRNA levels of PPARgamma target genes (LPL, CD36, aP2, and LXRalpha). 6-Thioinosine exerts its anti-adipogenic effects by downregulating PPARgamma through JNK-dependent iNOS upregulation. 6-Thioinosine can be used to study adipocyte dysfunction[1].
Molecular Weight:
284.30
Purity:
99.31
CAS Number:
[574-25-4]
Formula:
C10H12N4O4S
Target:
JNK,LXR,NO Synthase,PPAR
Application Notes:
Reference compound
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