SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity[1].
Molecular Weight:
1012.68
Purity:
98.64
CAS Number:
[2376047-73-1]
Formula:
C50H62ClN11O6S2
Target:
Bcr-Abl,PROTACs
Application Notes:
MCE Product type: Reference compound
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