COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 µM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].
Molecular Weight:
293.38
Purity:
99.92
CAS Number:
[906439-72-3]
Formula:
C18H15NOS
Target:
Poly(ADP-ribose) Glycohydrolase (PARG)
Application Notes:
MCE Product type: Reference compound
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