AM-6494 is a potent and orally active BACE1 (efficacious beta-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM)[1]. AM-6494 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molecular Weight:
473.50
CAS Number:
[1874232-80-0]
Formula:
C22H21F2N5O3S
Target:
Beta-secretase
Application Notes:
MCE Product type: Reference compound1
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