PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels[1][2].
Molecular Weight:
427.86
Purity:
99.60
CAS Number:
[874146-69-7]
Formula:
C15H11ClFN5O3S2
Target:
MDM-2/p53,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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