Dexloxiglumide is an orally active and selective cholecystokinin type A (CCKA) receptor antagonist. Dexloxiglumide is the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8). Dexloxiglumide exhibits moderate Caco-2 permeability that is polarized, concentration dependent, and pH dependent. Dexloxiglumide increases MRP1-substrate fluorescein uptake. Dexloxiglumide can be studied in research for gastrointestinal diseases and tumors[1][2][3].
Molecular Weight:
461.38
Purity:
98.25
CAS Number:
[119817-90-2]
Formula:
C21H30Cl2N2O5
Target:
Cholecystokinin Receptor,P-glycoprotein
Application Notes:
Reference compound
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