EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner[1].
Molecular Weight:
368.34
Purity:
99.42
CAS Number:
[1808714-73-9]
Formula:
C19H14F2N4O2
Target:
Autophagy
Application Notes:
MCE Product type: Reference compound
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