KL1333, a derivative of beta-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures[1][2].
Molecular Weight:
240.26
Purity:
99.94
CAS Number:
[1800405-30-4]
Formula:
C14H12N2O2
Target:
Mitochondrial Metabolism,Quinone Reductase
Application Notes:
MCE Product type: Reference compound
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