KL1333 (hydrochloride), CAS [[1800406-26-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-128895A
Supplier Catalog Number:
HY-128895A
Alternative Catalog Number:
MCE-HY-128895A-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
KL1333 hydrochloride is an orally active NAD+ modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD+ levels through NADH oxidation. Elevated NAD+ levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1alpha. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures[1][2].
Molecular Weight:
276.72
CAS Number:
[1800406-26-1]
Formula:
C14H13ClN2O2
Target:
Mitochondrial Metabolism,Quinone Reductase
Application Notes:
MCE Product type: Reference compound1
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