SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK, SK) inhibitor with an IC50 of 2 µM for GST-hSK. SKI V potently inhibits PI3K with an IC50 of 6 µM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity[1][2].
Molecular Weight:
254.24
Purity:
98.95
CAS Number:
[24418-86-8]
Formula:
C15H10O4
Target:
Apoptosis,PI3K,SphK
Application Notes:
MCE Product type: Reference compound
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