Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 µM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases[1][2][3].
Molecular Weight:
184.19
Purity:
99.58
CAS Number:
[778649-18-6]
Formula:
C9H12O4
Target:
Histone Acetyltransferase
Application Notes:
MCE Product type: Reference compound
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