TFMB-(R)-2-HG is a cell membrane-permeable (R)-2-HG and acute myeloid leukemia (AML) oncogenic factor. TFMB-(R)-2-HG competitively inhibits alpha-ketoglutarate-dependent dioxygenases such as KDM2B and FTO. TFMB-(R)-2-HG impairs cell differentiation in response to Estrogen withdrawal. TFMB-(R)-2-HG is used in acute myeloid leukemia and glioma research[1][2][3].
Molecular Weight:
288.22
Purity:
98.26
CAS Number:
[1445700-01-5]
Formula:
C13H11F3O4
Target:
Estrogen Receptor/ERR,Fat Mass and Obesity-associated Protein (FTO),Histone Demethylase
Application Notes:
MCE Product type: Reference compound
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