TFMB-(S)-2-HG is a potent TET2 inhibitor. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG downregulates Wnt3a, beta-catenin (intranuclear) protein expression. TFMB-(S)-2-HG inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML)[1][2].
Molecular Weight:
288.22
Purity:
99.79
CAS Number:
[1445703-64-9]
Formula:
C13H11F3O4
Target:
DNA Methyltransferase,TET/FET Family,Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound
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