N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
Molecular Weight:
357.50
CAS Number:
[31750-48-8]
Formula:
C25H27NO
Target:
Drug Metabolite,Endogenous Metabolite,Estrogen Receptor/ERR,PKC
Application Notes:
MCE Product type: Reference compound
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