N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
Molecular Weight:
393.95
Purity:
99.63
CAS Number:
[15917-65-4]
Formula:
C25H28ClNO
Target:
Drug Metabolite,Endogenous Metabolite,Estrogen Receptor/ERR,PKC
Application Notes:
MCE Product type: Reference compound
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