SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca2+ flux (IC50=38 nM), and antagonizes CXCL8-induced [(35)S]GTPgammaS binding (IC50=60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for inflammation suppression, in both humanized polymorphonuclear (PMN) cells and in murine model[1][2].
Molecular Weight:
382.22
Purity:
99.90
CAS Number:
[1240494-13-6]
Formula:
C19H16BFN2O3S
Target:
CXCR
Application Notes:
MCE Product type: Reference compound
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