AMG-8718 is a potent, selective and orally active BACE1 inhibitor with IC50 values of 0.0007, 0.005 µM for BACE1 and BACE2, respectively. AMG-8718 significantly decreases Abeta40 levels in the CSF and brain[1].
Molecular Weight:
442.44
CAS Number:
[1215868-94-2]
Formula:
C25H19FN4O3
Target:
Beta-secretase
Application Notes:
MCE Product type: Reference compound
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