Ala-ala-phe-chloromethylketone tfa, N-Ala-Ala-Phe-CMK, Tripeptidyl Peptidase inhibitor II
AAF-CMK TFA (Ala-ala-phe-chloromethylketone tfa, N-Ala-Ala-Phe-CMK) is a subtilisin-type serine peptidase that removes tripeptides from the free NH2 termini of oligopeptides. AAF-CMK TFA is an irreversible inhibitor of TPPII and is typically used at concentrations of 10-100 µM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at a concentration of 50 µM.
Molecular Weight:
453.84
CAS Number:
[184901-82-4]
Formula:
C18H23ClF3N3O5
Target:
Proteasome
Application Notes:
Peptides
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