A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (30-33) (CCK-4). A-70874 is an agonist that stimulates pancreatic amylase release and a partial agonist that stimulates pancreatic phosphoinositide decomposition. A-70874 has an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor. Cholecystokinin (CCK) receptors are divided into CCK-A (digestive tract) and CCK-B (brain). A-70874 has an affinity of 1.6 µM for the CCK-B/gastrin receptor[1].
Molecular Weight:
853.96
CAS Number:
[131449-37-1]
Formula:
C45H55N7O10
Target:
Cholecystokinin Receptor
Application Notes:
MCE Product type: Reference compound
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