SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 µM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36[1].
Molecular Weight:
835.79
Purity:
99.91
CAS Number:
[2429877-30-3]
Formula:
C40H44F2N7O9P
Target:
Ligands for Target Protein for PROTAC,STAT
Application Notes:
MCE Product type: Reference compound
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