KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF[1].
Molecular Weight:
949.52
Purity:
99.25
CAS Number:
[2384184-40-9]
Formula:
C50H65ClN4O12
Target:
FKBP,PROTACs
Application Notes:
MCE Product type: Reference compound
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