DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM. DM4-SMe is a highly toxic metabolite that can be oxidized and detoxified by human liver microsomes[1][2].
Molecular Weight:
826.46
Purity:
99.99
CAS Number:
[796073-68-2]
Formula:
C39H56ClN3O10S2
Target:
ADC Payload,Microtubule/Tubulin
Application Notes:
MCE Product type: ADC Related
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