Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].
Molecular Weight:
482.62
Purity:
99.94
CAS Number:
[1256580-46-7]
Formula:
C30H34N4O2
Target:
Anaplastic lymphoma kinase (ALK)
Application Notes:
MCE Product type: Reference compound
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