SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM, CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death[1].
Molecular Weight:
499.36
Purity:
99.82
CAS Number:
[2387704-62-1]
Formula:
C21H20Cl2N10O
Target:
Apoptosis,CDK
Application Notes:
MCE Product type: Reference compound
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