YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC50 of 0.30 µM. YQ128 significantly and selectively suppresses the production of IL-1beta, but not TNF-alpha, and it can cross the BBB to reach the CNS. YQ128 has anti-inflammatory activity[1]. YQ128 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molecular Weight:
545.11
Purity:
99.74
CAS Number:
[2454246-18-3]
Formula:
C27H29ClN2O4S2
Target:
Interleukin Related,NOD-like Receptor (NLR)
Application Notes:
MCE Product type: Reference compound
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