Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1alpha signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1beta and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders[1][2].
Molecular Weight:
360.49
Purity:
99.10
CAS Number:
[660430-03-5]
Formula:
C22H32O4
Target:
Akt,Caspase,Endogenous Metabolite,HIF/HIF Prolyl-Hydroxylase,Interleukin Related,MicroRNA,PI3K,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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