p-nitro-Pifithrin-alpha, a cell-permeable analog of pifithrin-alpha, is a potent p53 inhibitor. p-nitro-Pifithrin-alpha suppresses p53-mediated TGF-beta1 expression in HK-2 cells. p-nitro-Pifithrin-alpha inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-alpha attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease[1][2][3].
Molecular Weight:
398.27
Purity:
97
CAS Number:
[389850-21-9]
Formula:
C15H16BrN3O3S
Target:
Caspase,MDM-2/p53,TGF-beta Receptor
Application Notes:
MCE Product type: Reference compound
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