1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 µM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 µM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].
Molecular Weight:
187.19
Purity:
99.59
CAS Number:
[6953-61-3]
Formula:
C11H9NO2
Target:
HDAC
Application Notes:
MCE Product type: Reference compound1
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