TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM)[1].
Molecular Weight:
931.46
Purity:
99.63
CAS Number:
[2250025-88-6]
Formula:
C44H51ClN10O9S
Target:
CDK,PROTACs
Application Notes:
MCE Product type: Reference compound
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