c-Fms-IN-3 is an orally active c-Fms (CSF1R) kinase inhibitor (IC50 = 0. 8 nM). c-Fms-IN-3 inhibits CSF1R kinase activity and reduces macrophage populations. c-Fms-IN-3 reduces bone erosion, pannus invasion, cartilage damage, and inflammation in collagen (HY-NP003)-induced arthritis mouse model. c-Fms-IN-3 is useful for arthritis research[1][2].
Molecular Weight:
406.52
Purity:
99.69
CAS Number:
[885704-21-2]
Formula:
C23H30N6O
Target:
c-Fms,c-Kit,FLT3,TAM Receptor,Trk Receptor
Application Notes:
MCE Product type: Reference compound
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