Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC50s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants[1][2].
Molecular Weight:
551.61
Purity:
99.78
CAS Number:
[1505515-69-4]
Formula:
C29H34FN5O5
Target:
ROS Kinase
Application Notes:
Reference compound
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