FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
Molecular Weight:
442.51
Purity:
99.2
CAS Number:
[2226521-64-6]
Formula:
C25H26N6O2
Target:
JAK
Application Notes:
Reference compound
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